Quantity: 50 | 100 µg
Stock:
0.88 mg/ml (25 µM) in 50 mM HEPES pH 7.5, 200 mM NaCl, 10% Glycerol, 2 mM TCEP MW: 18 kDa (UBE2N), 17 kDa (UBE2V2)
Purity: >95 % by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie Blue stain.
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產品中心
UBE2N/UBE2V2 Complex
| 產品編號 | 規格 | 價格 | 貨期 | |
| UBE-5-14 | 100 μg | ￥1280 | 現貨 |
- 產品描述
- 技術特性
- 訂貨信息
- 資料下載
Ubiquitin-conjugating Enzyme E2N (UBE2N), also known as Ubiquitin-conjugating Enzyme 13 (Ubc13), forms a functional complex with the catalytically inactive UBE2V2 (human homologue of yeast MMS2) protein. Human UBE2N/Ubc13 shares 100% and 99% amino acid (aa) sequence identity with the mouse and rat orthologs, respectively, while human UBE2V2 shares 99% aa sequence identity with its mouse and rat orthologs. The UBE2N/UBE2V2 Complex functions with Ubiquitin ligases (E3s), including RNF111 and RNF8, to synthesize Lys63-linked Ubiquitin chains that can either be unanchored or attached to target proteins. The UBE2N/UBE2V2 complex has important roles in facilitating responses to various forms of DNA damage.